Sahel Motaghi; Hossein Jonaidi; Alireza Bashiri; Samaneh Nouri Gooshki
Abstract
Background Adenosine has many physiological roles in the brain, in rodents it changed food intake when applied centrally.Objective We investigated the effect of central injection of ...
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Background Adenosine has many physiological roles in the brain, in rodents it changed food intake when applied centrally.Objective We investigated the effect of central injection of the purine molecule adenosine on both food and fat intakes in neonatal chicks. Methods In the first trial, various doses of adenosine, and CGS15943 it’s synthetic antagonist, respectively, a P1 receptor endogenous agonist and it’s synthetic non specific antagonist were injected intracerebroventricularly (ICV) to the chicks and the cumulative food intake was measured at definite time intervals. The second trial was similar to the first one, but the chicks were fed with a high-fat diet. Result Adenosine did not affect food or fat intakes. Food consumption was increased 30-min after injection by CGS15943. CGS15943 also increased fat intake in chicks fed with the high-fat diet.Conclusion The present study suggests that in the avian central nervous system, P1 receptor s are entailed in the regulation of food and fat intakes in an antagonistic manner.
