TY - JOUR ID - 62036 TI - Evaluation of antioxidant potential of Aloe vera and pituitary sexual hormones after experimental diabetes in male rats. JO - Iranian Journal of Veterinary Medicine JA - IJVM LA - en SN - 2251-8894 AU - Behmanesh, Mohammad Amin AU - Efani Majd, Naeem AU - Shahriari, Ali AU - Nnajafzadeh, Hossein AD - Department of Histology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran AD - Department of Biochemistry, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran AD - Department of Pharmacology and Toxicology,Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran Y1 - 2017 PY - 2017 VL - 11 IS - 2 SP - 164 EP - 174 KW - Aloe Vera KW - diabet KW - anti oxidant KW - pituitary hormones KW - rat DO - 10.22059/ijvm.2017.62036 N2 - Background: Diabetes is a metabolic disease that is associated with hyperglycemia and infertility. Previous studies indicate that aloe vera may positively affect the blood glucose and fertility. Objective: the present study was carried out to evaluate effect of aloe vera on serum oxidant/antioxidant activity and reproductive hormones following experimental diabetes. Methods: sixty adults male wistar rats were divided to 5 groups. control group(A) was kept without treatment. Group(E) only received aloe vera gel(400 mg/kg-orally). Experimental diabete mellitus was induced in 3 groups of rats by streptozotocin( 65 mg/kg-Ip). One diabetic group was kept without treatment(B). Another diabetic group received aloe vera gel(400 mg/kg-orally)(C) and another received insulin(10 units)(D). Aloe vera gel and insulin was administration for 30 days then, the rats were anesthetized and blood collected. The amount of malondialdehid(MDA), anti oxidant activity(AOA), glutathion peroxidase activity(GPX), thiol protein(TSH), testosterone, LH and FSH was determined in serum. Results: level of testosterone was significantly decreased while amount of MDA, TSH, GPX and AOA was significantly increased in non-treated diabetic rats. Aloe vera increased antioxidant defense. Conclusions: Aloe vera improves antioxidant activity and reduces diabetic complications. Key words: Diabetes, Aloe vera, Anti oxidant, pituitary – sexual hormones, rat. UR - https://ijvm.ut.ac.ir/article_62036.html L1 - https://ijvm.ut.ac.ir/article_62036_70ea294050ec5b502d98620c47f80a79.pdf ER -