TY - JOUR ID - 65588 TI - The use of methylphenidate for emergence from propofol and ketamine anesthesia in dogs JO - Iranian Journal of Veterinary Medicine JA - IJVM LA - en SN - 2251-8894 AU - Imani Rastabi, Hadi AU - Avizeh, Reza AU - Kavosi, Narges AU - Sabiza, Soroush AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Y1 - 2018 PY - 2018 VL - 12 IS - 2 SP - 125 EP - 135 KW - anesthesia KW - emergence KW - ketamine KW - methylphenidate KW - propofol DO - 10.22059/ijvm.2018.238819.1004829 N2 - Background: Methylphenidate (MPH) has been used to induce emergence from general anesthesia. OBJECTIVES:  The objective of the present study was to evaluate the effect of MPH on recovery from propofol and ketamine anesthesia in dogs. METHODS: Six healthy male mix-breed dogs weighing 21.9 ± 3.9 kg were used in a randomized crossover design. Thirty minutes after premedication with acepromazine (0.1 mg/kg; IM), anesthesia was induced with either IV propofol or ketamine (8 and 15 mg/kg, respectively). Dogs, six minutes after induction, received either IV normal saline or methylphenidate (1 mg/kg) (propofol-saline; propofol-methylphenidate; ketamine-saline; ketamine-methylphenidate). Each dog was anesthetized four times randomly with at least one week interval. RESULTS: No significant differences were observed between propofol-saline and propofol-methylphenidate as well as between ketamine-saline and ketamine-methylphenidate in the times needed for various chronological sequences of recovery (p>0.05). Recovery in the dogs that received methylphenidate was eventful and associated with some adverse effects. Heart rate showed a decrease in propofol-methylphenidate group compared to the base (p<0.05). Respiratory rate after administration of methylphenidate was more stable than that of saline. CONCLUSIONS: It was concluded that methylphenidate at 1 mg/kg could not shorten recovery time in the dogs premedicated with acepromazine and anesthetized with either propofol or ketamine. Testing lower doses of methylphenidate and using a different premedication agent are recommended for future studies. UR - https://ijvm.ut.ac.ir/article_65588.html L1 - https://ijvm.ut.ac.ir/article_65588_bfda8676bddf9acd71fa5b8b6178fb4e.pdf ER -