TY - JOUR ID - 71291 TI - Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters JO - Iranian Journal of Veterinary Medicine JA - IJVM LA - en SN - 2251-8894 AU - Zakerian, Majid AU - Avizeh, Reza AU - Ghadiri, Alireza AU - Razi Jalali, Mohammad AU - Pourmahdi, Mahdi AU - Najafzadeh, Hosein AD - MVSc Graduated of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz. Ahvaz, Iran AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,Iran AD - Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran AD - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Y1 - 2019 PY - 2019 VL - 13 IS - 2 SP - 175 EP - 185 KW - colonoscopy KW - Dog KW - laxative KW - polyethylene glycol KW - senna DO - 10.22059/ijvm.2019.259726.1004901 N2 - Background: Colonoscopy is the preferred procedure for diagnosis of large-bowel diseases in dogs. Polyethylene glycol (PEG) is the most commonly used laxative for colonic cleansing. Senna has been used in traditional medicine as a laxative and an aid to treat constipation. OBJECTIVES: The aim of this study was to evaluate the safety of senna as an alternative or adjunct to polyethylene glycol solution in dogs using hematology and biochemistry. METHODS: For this purpose, 20 mongrel dogs were randomly allocated to receive 1 of 4 different bowel preparation regimens including PEG, senna or their combinations plus enema. Serum concentrations of sodium, potassium, total calcium, phosphorus, chloride, magnesium, PCV, total protein, ALT, AST, BUN and creatinine were measured at 0, 1, 2, 5, 6 and 24 hours after the first ingestion of laxative solutions. RESULTS: Statistical analysis showed that PEG or senna solutions had no significant effect on serum concentration of the evaluated parameters (P>0.05). Despite the significant changes in serum concentration of all measured parameters based on time of sampling in all groups, they were in their normal ranges (P>0.05). CONCLUSIONS: This is the first evaluation of the safety of bowel preparation with senna in dogs. This study showed that the use of PEG and senna for colon cleansing in dogs did not have any deleterious effects on their serum biochemical and electrolytes concentration. UR - https://ijvm.ut.ac.ir/article_71291.html L1 - https://ijvm.ut.ac.ir/article_71291_191a5af85af75236d3275d718a2a8c56.pdf ER -