TY - JOUR ID - 81250 TI - Evaluation of Cytokeratin 7 Expression in Different Mammary Gland Neoplasms JO - Iranian Journal of Veterinary Medicine JA - IJVM LA - en SN - 2251-8894 AU - Elahirad, Elnaz AU - Sasani, Farhang AU - Khosravi, Alireza AU - Gharagozlou, Mohammad Javad AU - Khanbarari, Fateme AD - Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran AD - Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran AD - Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Y1 - 2021 PY - 2021 VL - 15 IS - 1 SP - 56 EP - 67 KW - Cytokeratin 7 KW - dogs KW - Mammary neoplasms KW - Masson’s trichrome KW - myoepithelial cells DO - 10.22059/ijvm.2020.295956.1005052 N2 - BACKGROUND: Cytokeratins are non-contractile intermediate filaments engaged in anchoring and structural functions forming a network to support cytoplasm. Cytokeratin 7 (CK7) expression in human breast carcinomas has proved to be a useful differentiation marker, but its expression in canine mammary gland tumors is poorly understood. OBJECTIVES: Cytokeratin 7 (CK7) expression in human breast carcinomas has proved to be a useful differentiation marker, but its expression in canine mammary gland tumors is poorly understood. METHODS: This research was based on the immunohistochemical study of CK7 in 17 cases of canine mammary gland neoplasms obtained from the Department of Pathology, Faculty of Veterinary Medicine, University of Tehran. Masson’s trichrome staining was performed to differentiate between collagen fibers and smooth muscle. RESULTS: CK7 protein was detected in both epithelial (1 benign mixed tumor, 1 fibroadenoma, 1 complex carcinoma, and 1 carcinoma mixed type) and myoepithelial (1 fibroadenoma, 1 benign mixed tumor, 3 complex carcinomas, 1 ductal carcinoma, and 1 carcinoma mixed type) cells. Fine and thick collagen fibers were observed in the sections stained by Masson’s trichrome. CONCLUSIONS: Despite using CK7 as a differentiation marker in human breast cancer, CK7 had a controversial ex-pression in the epithelial and myoepithelial cells in canine mammary gland neoplasms. Based on the results, CK7 could not be considered as an independent marker for the canine mammary glands epithelial cell detection and a prognostic factor in canine mammary gland neoplasms UR - https://ijvm.ut.ac.ir/article_81250.html L1 - https://ijvm.ut.ac.ir/article_81250_0b8967f509661bea3686fb8cc819744d.pdf ER -