TY - JOUR ID - 88264 TI - Clinical Evaluation of the Effect of Methylprednisolone Sodium Succinate and Meloxicam in Experimental Acute Spinal Cord Injury JO - Iranian Journal of Veterinary Medicine JA - IJVM LA - en SN - 2251-8894 AU - Khodabakhshi Rad, Azin AU - Kazemi Mehrjerdi, Hossein AU - Pedram, Mir Sepehr AU - Azizzadeh, Mohammad AU - Amanollahi, Shiva AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. AD - Department of Surgery & Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Y1 - 2023 PY - 2023 VL - 17 IS - 2 SP - 129 EP - 138 KW - BBB (Basso KW - Beattie KW - and Bresnahan) test KW - Meloxicam KW - Methylprednisolone Sodium Succinate KW - Non-steroidal anti-inflammatory drugs (NSAIDs) KW - Spinal cord Injury (SCI) DO - 10.32598/ijvm.17.2.1005246 N2 - Background: Central nervous system (CNS) has limited repair capacity, and any spinal cord injury (SCI) can cause persistent disability in motor, sensory, and autonomic functions. The harmful reactions around the lesion must be stopped to prevent this consequence. Objectives: The present study compares the clinical effects of methylprednisolone sodium succinate (MPSS) and meloxicam in acute spinal cord injury in an animal model of rats. Methods: We randomly divided 24 male Wistar rats into 4 groups: 1) sham, 2) placebo, 3) SCI+MPSS (30 mg/kg, IV), and 4) SCI+meloxicam (1 mg/kg, SC). We used a Fogarty embolectomy catheter to induce a compression injury to the rats’ T8-T9 spinal cord segment. The drugs were injected one hour after surgery. Neurological evaluation was performed using BBB (Basso, Beattie, and Bresnahan) test immediately after recovery and then once a week for up to 6 weeks. Results: According to the BBB test results, single-dose administration of MPSS one hour after injury improved motor function significantly compared to placebo. But, there was no significant difference between MPSS and meloxicam groups and between meloxicam and placebo groups (P>0.01). Conclusion: In clinical evaluation, single-dose administration of MPSS one hour after injury improved motor function compared to meloxicam. UR - https://ijvm.ut.ac.ir/article_88264.html L1 - https://ijvm.ut.ac.ir/article_88264_753d5b0e9be765cc42362b1a23cdf449.pdf ER -