University of Tehran Iranian Journal of Veterinary Medicine 2251-8894 5 1 2011 03 01 The effect of dietary bovine colostrum supplementation on serum malondialdehyde levels and antioxidant activity in alloxan-induced diabetic rats اثر مکمل آغوز گاوی بر روی سطح مالون دآلدئید سرمی و فعالیت آنتی اکسیدانی در دیابت القاء شده با آلوکسان در رت 63 67 22674 10.22059/ijvm.2011.22674 EN ملیحه عباسعلی پورکبیره دانشکده دامپزشکی دانشگاه تهران Nahid Atyabi دانشکده دامپزشکی دانشگاه تهران Malihe Poorkabir دانشکده دامپزشکی دانشگاه تهران Ashkan Jebeli Javan دانشکده دامپزشکی دانشگاه سمنان Mehri Afshar دانشگاه علوم پزشکی زابل Journal Article 1970 01 01 Due to the range of its constituents, colostrum has been considered as a supplement for various diverse purposes. This study was conducted to examine the effect of supplementary bovine colostrum on serum malondialdehyde (MDA), antioxidant activity (AOA) and glucose in a diabetic rodent model. Sixty male Wistar rats were divided into 10 groups of six rats each for 40 days as follows: non-diabetic; diabetic; diabetic with 10%, 20% or 30% colostrum intake; non-diabetic with 10%, 20% or 30% colostrum intake; diabetic treated with insulin; and diabetic treated with glibenclamide. Although serum MDA levels showed a significant decrease in response to insulin (2.56 ± 0.31 µmol/L) and 10%, 20% or 30% colostrum intake (0.46 ± 0.04, 0.29 ± 0.06, 0.37 ± 0.09 µmol/L, respectively), the decrease was greater in the diabetic rats (3.92 ± 0.29 µmol/L) (p < 0.01). Significant changes were seen in the AOA of both insulin (0.78 ± 0.11 mmol/L) and glibenclamide (0.7 ± 0.08 mmol/L) treated rats compared to the diabetic rats (0.69 ± 0.1 mmol/L); however, AOA showed a significant increase in response to 10% (1.78 ± 0.11 mmol/L), 20% (1.57 ± 0.02 mmol/L) and 30% (1.75 ± 0.02 mmol/L) colostrum (p < 0.001). All treated groups showed a significant decrease in serum glucose levels compared to the diabetic group (391 ± 39.79 mg/dL) (p < 0.01). It seems that colostrum might be a beneficial dietary supplement for reducing serum MDA and glucose levels while increasing serum AOA in type1 diabetes mellitus. https://ijvm.ut.ac.ir/article_22674_cea19496d1dcf1aa02fc7bd2f706a40d.pdf