University of Tehran Iranian Journal of Veterinary Medicine 2251-8894 8 3 2014 10 01 Urinary oxalate, citrate, and gamma glutamyl transferase alterations after administration of Cynodon dactylon extract in cats تغییرات اگزالات، سیترات و گاما گلوتامیل ترانسفراز ادرار پس از تجویز عصاره ی Cynodon dactylon به گربه ها 193 198 51891 10.22059/ijvm.2014.51891 EN Saeedeh Janitabar Department of Internal Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Abdolali Malmasi Department of Internal Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Gholam Reza Amin Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Saied Bokaie Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran 0000-0003-3505-0270 Mohammad Molazem Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran 0000-0003-4038-4849 Fataneh Naderinezahad Department of Internal Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran R Sharifi Department of Internal Diseases, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Journal Article 2014 01 08 BACKGROUND: Urinary oxalate and citrate are the key<br />factors in caox urolithiasis of cats and Gamma Glutamyl<br />Transferase is a good test for assessment of kidney damage.<br />Favorable effects of Cynodon dactylon on calcium oxalate stone<br />formation have recently been proved in rats. OBJECTIVES: The<br />present study was designed to investigate the alteration of<br />urinary oxalate, citrate, and GGT after administration of the<br />hydroalcoholic extract of Cynodon dactylon to experimental<br />hyperoxaluric cats. No scientific study has been done so far to<br />demonstrate the beneficial effect of this plant in cats. METHODS:<br />13 mature male cats were randomly divided into 3 groups: group<br />Areceived standard diet and drinking water while, group B and<br />C also received ethylene glycol at sub-toxic dose (130 mg/kg)<br />daily for 30 days. Group C received hydroalcoholic extract of<br />C.dactylon (400 mg/kg) from day 0 to 30, as well. Urine samples<br />were collected on days 0, 15, and 30 and were analyzed for<br />oxalate, citrate, and GGT levels. RESULTS: Urine oxalate level<br />in group B was significantly higher than group C on days 15 and<br />30. Urinary citrate excretion was significantly higher in group C<br />compared to the other groups on day 15; however, it decreased<br />during the entire experiment in groups B and C. Urinary Gamma<br />Glutamyl Transferase level was increased in hyperoxaluric cats<br />and decreased in the treated group during the experiment.<br />CONCLUSIONS: Based on our results, C.dactylon extract could<br />reduce the hyperoxaluria and has beneficial effects on<br />preventing the renal damage in cats. Such findings provide a<br />scientific explanation for applying C.dactylon in prevention and<br />possible treatment of CaOx kidney stones in cats and humans. https://ijvm.ut.ac.ir/article_51891_503cd3ce8f9762db3e425bda538cf1c4.pdf