University of Tehran Iranian Journal of Veterinary Medicine 2251-8894 12 1 2018 01 01 Observation of squamous cell carcinoma in a goat flock in Iran مشاهده کارسینوم سلول‌های سنگفرشی در یک گله بز در ایران 79 84 64496 10.22059/ijvm.2017.243100.1004847 EN ‌Arash Omidi Department of Animal Health Management, School of Veterinary Medicine, Shiraz University, Shiraz Fatemeh Namazi Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Hamidreza Pourmirzaei Veterinary Master Bureau of Yazd province, Yazd, Iran Mahdi Mohebbi-Fani Department of Animal Health Management, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Journal Article 2017 09 10 Squamous cell carcinoma (SCC) is a tumor consisting of squamous epithelial cells. This tumor is relatively uncommon in goats. In this report, we discuss clinical, gross and histopathological features of SCC in six goats. The goats were referred to the veterinary clinic with a progressive ulcerative and hemorrhagic mass located in the perineal area. The vital signs (temperature, pulse rate, respiration rate) were normal. Biopsy specimens were taken and histopathological examinations were done. The tumor cells were large and had an abundant eosinophilic cytoplasm, ovoid nuclei with a prominent nucleolus. Keratin tonofibers and keratin pearls were also seen. The mitotic figures were moderate. The mass was found to be a moderately differentiated SCC. Ulceration with infiltration of neutrophils was observed on the surface of the tumors. The SCC tumors are uncommon in goats and have multi-factorial etiology. Age, ultraviolet (UV) light exposure, lack of epidermis pigmentation, and viruses may be involved in the presence of SCC. https://ijvm.ut.ac.ir/article_64496_a38fc0d94e76fadfbeeae958b246b04f.pdf