University of Tehran Iranian Journal of Veterinary Medicine 2251-8894 13 2 2019 04 01 Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters تأثیر آمادهسازی روده با پلیاتیلنگلیکول و سنا در سگ بر برخی پارامترهای بیوشیمیایی و هماتولوژی سرم 175 185 71291 10.22059/ijvm.2019.259726.1004901 EN Majid Zakerian MVSc Graduated of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Reza Avizeh Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz. Ahvaz, Iran Alireza Ghadiri Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,Iran Mohammad Razi Jalali Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,Iran Mahdi Pourmahdi Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Hosein Najafzadeh Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran Journal Article 2019 01 09 <span style="color: windowtext; text-transform: uppercase; font-family: 'Times New Roman','serif'; font-size: 12pt; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-font-family: TimesNewRomanPS-BoldMT;">Background: Colonoscopy is the preferred procedure for diagnosis of large-bowel diseases in dogs. Polyethylene glycol (PEG) is the most commonly used laxative for colonic cleansing. Senna has been used in traditional medicine as a laxative and an aid to treat constipation. OBJECTIVES: The aim of this study was to evaluate the safety of senna as an alternative or adjunct to polyethylene glycol solution in dogs using hematology and biochemistry. METHODS: For this purpose, 20 mongrel dogs were randomly allocated to receive 1 of 4 different bowel preparation regimens including PEG, senna or their combinations plus enema. Serum concentrations of sodium, potassium, total calcium, phosphorus, chloride, magnesium, PCV, total protein, ALT, AST, BUN and creatinine were measured at 0, 1, 2, 5, 6 and 24 hours after the first ingestion of laxative solutions. RESULTS: Statistical analysis showed that PEG or senna solutions had no significant effect on serum concentration of the evaluated parameters (P>0.05). Despite the significant changes in serum concentration of all measured parameters based on time of sampling in all groups, they were in their normal ranges (P>0.05). CONCLUSIONS: This is the first evaluation of the safety of bowel preparation with senna in dogs. This study showed that the use of PEG and senna for colon cleansing in dogs did not have any deleterious effects on their serum biochemical and electrolytes concentration.

https://ijvm.ut.ac.ir/article_71291_191a5af85af75236d3275d718a2a8c56.pdf