University of Tehran Iranian Journal of Veterinary Medicine 2251-8894 16 3 2022 08 01 Major Histocompatibility Complex as Marker Assisted Selection for Breeding Immunocompetent Animal مجتمع عمده پذیرش بافتی به عنوان شاخص انتخاب برای پرورش حیوان ایمن 211 227 87632 10.22059/ijvm.2022.339598.1005251 EN Gholamreza Nikbakht Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Pouya Houshmand Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Atefeh Esmailnejad Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Fatemeh Abasabadi Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Journal Article 2022 03 09  <br /><span style="color: #221f1f; font-size: small;">Due to the threat of vaccination problems and antibiotic resistance, more appropriate approaches are desired to breed disease resistance animals that are now practiced in cattle, sheep, chicken, and fish farming. Over the recent century, breeding programs based on the productive characteristics have increased animals' overall growth rate and produc-tivity. Despite the benefits, livestock breeding with this method has caused many physiological disorders as well as a reduction in overall immunocompetence. This issue highlights the importance of genetic considerations during the process of breeding. One of the most crucial gene clusters identified in animals is the major histocompatibility complex (MHC), which plays a crucial role in the immune system to distinguishing self from non-self. Recent studies have demonstrated that some MHC regions are highly polymorphic. Also, a significant association between different MHC alleles and susceptibility/ resistance to various diseases has been found. This review summarizes the recent research on MHC polymorphism and its association with immune responses in domestic animals </span> https://ijvm.ut.ac.ir/article_87632_a9ebc9070a2a90e4086be119ab7c0178.pdf