University of Tehran Iranian Journal of Veterinary Medicine 2251-8894 17 2 2023 04 01 Clinical Evaluation of the Effect of Methylprednisolone Sodium Succinate and Meloxicam in Experimental Acute Spinal Cord Injury ارزیابی بالینی اثر متیل پردنیزولون سدیم سوکسینات و ملوکسیکام در آسیب حاد نخاعی تجربی 129 138 88264 10.32598/ijvm.17.2.1005246 EN Azin Khodabakhshi Rad Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Hossein Kazemi Mehrjerdi Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. 0000-0002-5593-6864 Mir Sepehr Pedram Department of Surgery & Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. 0000-0002-4740-6994 Mohammad Azizzadeh Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Shiva Amanollahi Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. 0000-0002-8656-3079 Journal Article 2022 03 28 <strong>Background</strong>: Central nervous system (CNS) has limited repair capacity, and any spinal cord injury (SCI) can cause persistent disability in motor, sensory, and autonomic functions. The harmful reactions around the lesion must be stopped to prevent this consequence. <br /><strong>Objectives</strong>: The present study compares the clinical effects of methylprednisolone sodium succinate (MPSS) and meloxicam in acute spinal cord injury in an animal model of rats. <br /><strong>Methods</strong>: We randomly divided 24 male Wistar rats into 4 groups: 1) sham, 2) placebo, 3) SCI+MPSS (30 mg/kg, IV), and 4) SCI+meloxicam (1 mg/kg, SC). We used a Fogarty embolectomy catheter to induce a compression injury to the rats’ T8-T9 spinal cord segment. The drugs were injected one hour after surgery. Neurological evaluation was performed using BBB (Basso, Beattie, and Bresnahan) test immediately after recovery and then once a week for up to 6 weeks. <br /><strong>Results</strong>: According to the BBB test results, single-dose administration of MPSS one hour after injury improved motor function significantly compared to placebo. But, there was no significant difference between MPSS and meloxicam groups and between meloxicam and placebo groups (P>0.01). <br /><strong>Conclusion</strong>: In clinical evaluation, single-dose administration of MPSS one hour after injury improved motor function compared to meloxicam. https://ijvm.ut.ac.ir/article_88264_e0b250a3123283d06804526510b5443e.pdf