Iranian Journal of Veterinary Medicine

Iranian Journal of Veterinary Medicine

Developmental changes in Endothelin-1 and Endothelin type A receptor expression in the lungs of chickens (Broiler versus layer)

Authors
Lohrasb Shahgholian 1
Mosoud Teshfam 1
پیمان اسدیان 2
Hosein Hasanpour 2
غلامرضا نیکبخت بروجنی 3
1 گروه فیزیولوژی دامپزشکی، دانشکده علوم تخصصی دامپزشکی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات
2 گروه علوم درمانگاهی، دانشکده دامپزشکی دانشگاه لرستان
3 گروه میکروبیولوژی،دانشکده دامپزشکی دانشگاه تهران
10.22059/ijvm.2012.30229
Abstract
Background: Broilers lung mechanisms that regulate endothelin (ET) in the lung are complex and poorly understood. Objectives: Methods: In this experiment lung ET-1 mRNA levels and lung mRNA expression for the ET(A) receptors were determined in lung tissue weekly (term = 42 days, intervals = 7 days). Serum endothelin concentration was also measured at these ages. Results: The study showed that expression of endothelin in lungs of layers and broilers was similar during the first three weeks and the overall trend of ET-1 expression was increasing. However, there was a significant increase of ET-1 expression which started from the fourth week and gradually increased until the end of the commercial life of the chicken (day 42). ET-A expression in the lungs of broilers was significantly higher than layers during the last three weeks of life. Overall, trends of serum ET-1 concentration increased in both layers and broilers, but serum ET-1 concentration in broilers was significantly higher than layers. Conclusions: The higher level of serum Endothelin and expression of ET-1 and ETA in broiler lungs may explain the higher sensitivity of broilers to the vasoconstrictions activity of endothelin and the higher sensitivity of these animals to pulmonary hypertension (PH).
Iranian Journal of Veterinary Medicine
Volume 6, Issue 4 - Serial Number 1369670
17 Iranian Journal of Veterinary Medicine
November and December 2012
Pages 241-247