Document Type : Original Articles
Authors
1
Student Research Committee, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
2
Department of Pathobiology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
3
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran
10.22059/ijvm.2025.388644.1005723
Abstract
Background: Chronic prostatitis is one of the most common diseases of the prostate gland, significantly impacting men's quality of life. Today, Metformin is recognized as a medicine with multiple therapeutic potentials, including enhanced anti-inflammatory and antioxidant activity, antitumor effects, benign prostatic hyperplasia, and more.
Objective: The present study aims to investigate the histopathological effects of metformin on chronic non-bacterial prostatitis (CNP) induced by carrageenan in rats.
Methods: Twenty-four male rats were divided into four groups (n=6): Group I (Sham: pseudo CNP-Untreated), II (Control: CNP-Untreated), III (Cernilton: CNP-Standard Treatment), and IV (MET: CNP-Under Treatment). To induce CNP, 0.1 mm carrageenan (1%) was injected into the prostate of groups II, III, and IV. In contrast, an equal amount of normal saline was injected into Group I. Subsequently, rats in Group IV were treated with MET (100 mg/kg), III with Cernilton (100 mg/kg), and I and II with 0.5 ml normal saline, orally daily for up to 3 weeks (21 days). After 21 days, the rats were euthanized, and prostate tissue sections were prepared for histological staining with hematoxylin-eosin.
Results: Group IV had a significant difference in inflammation compared to Group II (P < 0.05). Additionally, from a histopathological perspective, Group IV exhibited a significant reduction in inflammation but in hyperplasia of acinar epithelial cells and hyperemia although there is no significant changes between all groups but reduction of hyperplasia and increase the hyperemia were considerable in Group IV, with the tissue appearance closely resembling that of normal prostate tissue.
Conclusion: In the present study, it has been demonstrated for the first time that Metformin reduces tissue inflammation and its associated complications in the prostate.
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