Document Type : Original Articles
Authors
1
departement of clinical science, veterinary medicine, university of tehran, tehran, iran
2
1. Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3
2. The Pirbright Institute, Ash Road, Pirbright GU24 0NF, UK.
4
The Pirbright Institute, Ash Road, Pirbright GU24 0NF, UK
5
3. Department of pathobiology of veterinary faculty, Islamic azad university, karaj branch, karaj,iran
6
4. Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
10.22059/ijvm.2025.398043.1005842
Abstract
Background: Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals such as cattle, pigs, sheep, goats, and various wild species like deer and buffalo.
Aim: this study was conducted to investigate the levels of maternally derived antibodies (MDA) against FMDV in calves of different ages in Iran.
Material and method: This study was conducted on a large dairy cattle farm located in Qazvin Province, Iran (Sharif Abad Dairy Cattle Farm). Thirteen calves aged 45 days, thirteen aged 75 days, and thirteen aged 95 days were selected for the study. None of studied calves received vaccination against FMD. Blood samples were collected from each of them. Serological analysis was conducted at The Pirbright Institute, UK, by the FAO World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD).
Result: At age of 45, 75 and 95 days old, mean virus neutralization titers were 2.54, 2.09 and 1.92, respectively. Up to 95 days of age, the mean virus neutralization titers (VNTs) remained above the threshold predicted for 50% homologous protection (1.4). Notably, at 45 days of age, all calves exhibited VNTs (2.54 ± 0.17) exceeding the threshold predicted for 95% homologous protection (2.1). The mean VNT (2.09 ± 0.28) at 75 days of age was almost equal to the threshold predicted for 95% homologous protection (2.1).
Conclusion: Calves up to 95 days of age maintain adequate protection against FMD and do not require vaccination during this period.
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