Document Type : Original Articles
Authors
1
Graduate student, Faculty of Veterinary Medicine, SR.C, Islamic Azad University, Tehran, Iran
2
Assistant Professor, department of Physiology Faculty of Veterinary Medicine Science and Research Branch Islamic Azad University-Tehran-Iran
3
Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
10.22059/ijvm.2025.396006.1005815
Abstract
BACKGROUND: Glucocorticoid-induced hypercortisolism, a common complication of prolonged dexamethasone use, disrupts metabolic and endocrine homeostasis. Current therapeutic strategies remain limited, necessitating novel interventions. Resveratrol, a polyphenol with anti-inflammatory and antioxidant properties, shows potential in modulating glucocorticoid signaling. This study investigates its efficacy in mitigating dexamethasone-induced hypercortisolism in a rat model.
OBJECTIVES: of resveratrol on blood parameters in alleviating dexamethasone-induced hypercortisolism in Wistar rats.
METHODS: Twenty-four male Wistar rats were obtained from the Pasteur Institute of Iran and randomly allocated to four groups: (1) untreated control; (2) hypercortisolism induction via oral dexamethasone (100 μg/kg) for 4 weeks; (3) co-administration of dexamethasone dexamethasone (100 μg/kg) and ketoconazole (5 mg/kg) for 4 weeks; and (4) co-administration of dexamethasone (100 μg/kg) and resveratrol (80 mg/kg) for 4 weeks. Serum biomarkers—cortisol, glucose, triglycerides, cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), creatinine and total protein (TP) were then analyzed.
RESULTS: Neither ketoconazole nor resveratrol significantly altered body weight in hypercortisolemic rats (P = 0.45). Dexamethasone and dexamethasone-ketoconazole administration elevated serum cortisol, whereas resveratrol attenuated serum cortisol levels (P = 0.022). Dexamethasone increased serum glucose, cholesterol, triglycerides, and LDL (P = 0.011), while reducing HDL (P = 0.014) and TP; resveratrol reversed the changes in these blood parameters (P = 0.027).
CONCLUSIONS: These findings indicate that resveratrol attenuates the biochemical alterations associated with experimental hypercortisolism, underscoring its potential utility as a therapeutic agent in the management of hypercortisolism disorders.
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