Document Type : Original Articles
Authors
1
Basic Science Department, College of dentistry, Mustansiriyah University, Baghdad, Iraq.
2
Department of Basic Science, College of Dentistry, Al-Iraqia University, Baghdad, Iraq
3
College of Medicine, Ibn Sina University of Medical and Pharmaceutical Science, Baghdad, Iraq
10.22059/ijvm.2026.414677.1006088
Abstract
Background: One of the most common macrolide antibiotics is erythromycin. Several cardiac effects, including ROS and MI, may be linked to its use, nevertheless. Alternatively, thiamine (vitamin B1) has anti-inflammatory with antioxidants characteristics in addition to being an important cofactor in energy metabolism. Examining the possible protective function of thiamine against cardiovascular damage in adult white rats generated by erythromycin was the primary objective of this investigation. Methods: Forty male Swiss white rats were randomly divided into four groups (10 rats per group): control (G1, saline), thiamine G2 (50 µg/kg), erythromycin G3 (15 mg/kg), and G4 (thiamine + erythromycin at doses of 50 µg/kg + 15 mg/kg). they given orally for 30 day. Several serum biochemical markers were measured, including (MDA), (GSH), (CK), (AST), lipid profile, (CRP), and (IL-6). Histological examination of the myocardium and aorta was also performed using hematoxylin and eosin (H&E) staining. Results: (G1) showed normal values : MDA (2.1 ± 0.3 nmol/mL), GSH (8.2 ± 1.0 µmol/L), CK (145 ± 20 U/L), AST (60 ± 8 U/L), lipids (cholesterol 145 ± 12, triglycerides 110 ± 10, LDL 65 ± 8, HDL 52 ± 6 mg/dL), CRP (1.2 ± 0.2 mg/L), and IL-6 (18 ± 3 pg/mL). G2 remained close to the control group with a slight improvement in GSH (9.0 ± 1.2) and HDL (55 ± 5). In contrast, G3 showed a marked increase in MDA (4.5 ± 0.6), CK (380 ± 40), AST (140 ± 15), lipids (cholesterol 220 ± 20, triglycerides 180 ± 15, LDL 120 ± 12 mg/dL), CRP (4.8 ± 0.6), and IL-6 (45 ± 5), with a decrease in GSH (4.0 ± 0.8) and HDL (30 ± 4). G4 showed a marked improvement compared to G3, with a decrease in elevated values and improvements in GSH (7.5 ± 1.1) and HDL (48 ± 5). Conclusion: Thiamine administration demonstrated a significant effect against erythromycin-induced vascular toxicity by enhancing antioxidant defenses and biomarkers.
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