Ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (GH)-releasing effect in the pituitary. It also increases appetite and feeding behavior. Recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. In this study, the effect of chronically administered ghrelin on the histomorphometrical properties of stomach and different parts of intestinal mucosa were evaluated in a rat model. Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P<0.05). Chronic administration of ghrelin could therefore exert a gastrointestinal protective effect, as it promotes mucosal growth in the proximal gut and enhances gastric glands in oxyntic mucosa.
Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P<0.05). Chronic administration of ghrelin could therefore exert a gastrointestinal protective effect, as it promotes mucosal growth in the proximal gut and enhances gastric glands in oxyntic mucosa.
زنده دل, م. , Taati, M. , Kheradmand, A. , Sheikhzadeh, F. and Zendehdel, M. (2011). Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat. Iranian Journal of Veterinary Medicine, 5(3), 173-177. doi: 10.22059/ijvm.2011.23845
MLA
زنده دل, م. , , Taati, M. , , Kheradmand, A. , , Sheikhzadeh, F. , and Zendehdel, M. . "Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat", Iranian Journal of Veterinary Medicine, 5, 3, 2011, 173-177. doi: 10.22059/ijvm.2011.23845
HARVARD
زنده دل, م., Taati, M., Kheradmand, A., Sheikhzadeh, F., Zendehdel, M. (2011). 'Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat', Iranian Journal of Veterinary Medicine, 5(3), pp. 173-177. doi: 10.22059/ijvm.2011.23845
CHICAGO
م. زنده دل , M. Taati , A. Kheradmand , F. Sheikhzadeh and M. Zendehdel, "Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat," Iranian Journal of Veterinary Medicine, 5 3 (2011): 173-177, doi: 10.22059/ijvm.2011.23845
VANCOUVER
زنده دل, م., Taati, M., Kheradmand, A., Sheikhzadeh, F., Zendehdel, M. Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat. Iranian Journal of Veterinary Medicine, 2011; 5(3): 173-177. doi: 10.22059/ijvm.2011.23845
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