Iranian Journal of Veterinary Medicine

Iranian Journal of Veterinary Medicine

Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat

Authors
مرتضی زنده دل 1
Majid Taati 2
Arash Kheradmand 2
Farzam Sheikhzadeh 1
Morteza Zendehdel 3
1 گروه زیست شناسی جانوری، دانشکده علوم طبیعی دانشگاه تبریز، تبریز
2 گروه پاتوبیولوژی، دانشکده دامپزشکی دانشگاه لرستان، خرم آباد
3 گروه علوم پایه، دانشکده دامپزشکی دانشگاه تهران
10.22059/ijvm.2011.23845
Abstract
Ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (GH)-releasing effect in the pituitary. It also increases appetite and feeding behavior. Recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. In this study, the effect of chronically administered ghrelin on the histomorphometrical properties of stomach and different parts of intestinal mucosa were evaluated in a rat model. Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P<0.05). Chronic administration of ghrelin could therefore exert a gastrointestinal protective effect, as it promotes mucosal growth in the proximal gut and enhances gastric glands in oxyntic mucosa.
Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P<0.05). Chronic administration of ghrelin could therefore exert a gastrointestinal protective effect, as it promotes mucosal growth in the proximal gut and enhances gastric glands in oxyntic mucosa.
Iranian Journal of Veterinary Medicine
Volume 5, Issue 3 - Serial Number 714077
12 International Journal Of Veterinary Research
September and October 2011
Pages 173-177