BACKGROUNDS: Seminoma is frequently observed in human and canine testes especially in cryptorchids. Canine and human seminomas are typically associated with leukocytic infiltration. OBJECTIVES: We aimed to identify the type of lymphocytes that infiltrate to seminomas. METHODS: Tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. Routine pathological examination of these specimens showed diffuse seminoma with tumor infiltrating lymphocytes in all cases. RESULTS: Lymphocytes in seminomas were predominantly T cytotoxic (CD3+, CD8+) cells. These cells were distributed diffusely, but patchy around the vessels. B-cells were also identified as some rare single cells diffusely scattered in the tumoral parenchyma. CONCLUSIONS: The results of this study showed that the lymphocyte infiltrating cells are mainly T lymphocytes particularly CD8 cytotoxic type.
BACKGROUNDS: Seminoma is frequently observed in human and canine testes especially in cryptorchids. Canine and human seminomas are typically associated with leukocytic infiltration. OBJECTIVES: We aimed to identify the type of lymphocytes that infiltrate to seminomas. METHODS: Tumor infiltrating lymphocytes were evaluated by immunohistological techniques in 5 dogs with diffuse seminoma. Routine pathological examination of these specimens showed diffuse seminoma with tumor infiltrating lymphocytes in all cases. RESULTS: Lymphocytes in seminomas were predominantly T cytotoxic (CD3+, CD8+) cells. These cells were distributed diffusely, but patchy around the vessels. B-cells were also identified as some rare single cells diffusely scattered in the tumoral parenchyma. CONCLUSIONS: The results of this study showed that the lymphocyte infiltrating cells are mainly T lymphocytes particularly CD8 cytotoxic type.
Hesaraki, S. (2012). Immunohistochemical evaluation of lymphocyte types infiltrate into the canine seminomas. Iranian Journal of Veterinary Medicine, 6(1), 29-32. doi: 10.22059/ijvm.2012.24622
MLA
Hesaraki, S. . "Immunohistochemical evaluation of lymphocyte types infiltrate into the canine seminomas", Iranian Journal of Veterinary Medicine, 6, 1, 2012, 29-32. doi: 10.22059/ijvm.2012.24622
HARVARD
Hesaraki, S. (2012). 'Immunohistochemical evaluation of lymphocyte types infiltrate into the canine seminomas', Iranian Journal of Veterinary Medicine, 6(1), pp. 29-32. doi: 10.22059/ijvm.2012.24622
CHICAGO
S. Hesaraki, "Immunohistochemical evaluation of lymphocyte types infiltrate into the canine seminomas," Iranian Journal of Veterinary Medicine, 6 1 (2012): 29-32, doi: 10.22059/ijvm.2012.24622
VANCOUVER
Hesaraki, S. Immunohistochemical evaluation of lymphocyte types infiltrate into the canine seminomas. Iranian Journal of Veterinary Medicine, 2012; 6(1): 29-32. doi: 10.22059/ijvm.2012.24622