The first study of bovine immunodeficiency virus (BIV) and brucellosis co-infection in west-central Iran

Document Type : Infectious agents- Diseases

Authors

1 Department of Pathobiology, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran

2 Department of Virology, Veterinary Laboratories Agency, Addlestone, United Kingdom

Abstract

Background: BIV is a well-known bovine immunosuppressive cause, but its pathogenesis has not been well characterized. In recent years, it has been hypothesized that infection with BIV might predispose cattle to be infected by other agents. OBJECTIVE: This study was performed to investigate of BIV and Brucella co-infection so that in the future more studies will be done on the issue of predisposing cattle to other microorganisms like Brucella after BIV infection. METHODS: Blood samples were collected from a total of 2290 cattle in Iran (490 and 1800 cattle in non-industrial and industrial dairy farms, respectively from Isfahan and Chaharmahal and Bakhtiari provinces). The BIV-positive animals were detected by Lab-ELISA and nested PCR tests. RESULTS: In this study, the overall prevalence of BIV in Iran was 1.61% (4.5% and 0.83% in non-industrial and industrial dairy farms, respectively). CONCLUSIONS: There was a statistically significant relationship between BIV status and Brucella infection using Chi square and Pearson’s correlation coefficient test for all of the samples (p=0.0001, r=0.24), samples from Chaharmahal and Bakhtiari (p=0.044, r=0.13) and from industrial farms in Isfahan (p=0.001, r=0.074).

Keywords

Article Title [Persian]

اولین مطالعه عفونت توأم ویروس نقصان ایمنی گاو و بروسلوز در نواحی مرکزی و غربی ایران

Authors [Persian]

  • اعظم مختاری 1
  • محمدرضا محزونیه 1
  • ژان پیر فروسارد 2
1 گروه پاتوبیولوژی، دانشکده دامپزشکی دانشگاه شهرکرد، شهرکرد، ایران
2 گروه ویروس شناسی، آزمایشگاه VLA ، ویبریج، انگلستان
Abstract [Persian]

زمینه مطالعه: ویروس نقصان ایمنی گاو یکی از اجرام بیماریزای شناخته شده به عنوان یک عامل سرکوب کننده سیستم ایمنی گاو است اما روند بیماریزایی آن به خوبی مشخص نشده است. در سال‌های اخیر، این فرضیه مطرح شده است که عفونت با BIV گاو را به آلوده شدن به سایر عوامل بیماریزا مستعد می‌نماید. هدف: هدف از این مطالعه جستجوی عفونت توأم BIV و بروسلا است تا در آینده مطالعات بیشتری در مورد مستعد شدن گاو به ابتلا به سایر میکروارگانیسم‌ها نظیر بروسلا پس از عفونت با BIV انجام شود. روش کار: تعداد 2290 نمونه خون گاو از فارم‌های غیر صنعتی (490=n) و صنعتی (1800=n) پرورش گاو شیری واقع در استان‌های چهار محال و بختیاری و اصفهان، ایران، اخذ گردید. حیوانات آلوده به BIV با آزمون‌های Lab- ELISA و nested PCR شناسایی شدند. نتایج: میزان کلی شیوع BIV، 61/1% محاسبه شد (7/5% و 83/0% به ترتیب در فارم‌های غیرصنعتی و صنعتی). نتیجه‌گیری‌نهایی: با استفاده از آزمون‌های آماری مربع کای و ضریب همبستگی پیرسون ارتباط معنی‌داری بین وضعیت آلودگی به BIV و بروسلوز در مورد کل نمونه‌ها (0001/0=p ،24/0=r) و نمونه‌های مربوط به چهارمحال و بختیاری (044/0=p ،13/0=p) و در فارم‌های صنعتی اصفهان (001/0=p ،074/0=p) دیده شد.

Keywords [Persian]

  • ویروس نقصان ایمنی گاو
  • بروسلا
  • شیوع سرمی

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