A Brief Review of Synthesis Methods, Biological Activities and Cytotoxicity of Cerium Oxide Nanoparticles

Articles in Press

Document Type : Review article

Authors

1 Department of Basic Science, Faculty of Veterinary Medicine, Shahrekord University, shahrekord, Iran

2 Department of Pathobiology, Faculty of Veterinary Medicine, Islamic Azad University, shahrekord, Iran

Abstract

Cerium oxide nanoparticles (CeO2-NPs, or nanoceria) are among the most unique and promising lanthanide nanomaterials, with unique properties such as their redox activity, oxygen storage capacity, and free radical scavenging ability. Their ability to self-regenerate their surface makes them a potential candidate in different fields, especially the biomedical division. The mechanisms by which nanoceria protect against oxidative stress include the direct scavenging of radicals by mimicking the catalytic activity of redox enzymes. Nanoceria can act as a double-edged sword and display both oxidant and antioxidant properties, depending on surface characteristics and the environment. In spite of their potential for clinical applications, there are also contradictory studies reporting the potential toxicity of CNPs. This review describes: (1) the methods of synthesis for CeO2-NPs; (2) the applications of nanoceria for antioxidant, anti-inflammatory, and anticancer activities, including the most recent studies carried out in vivo and in vitro; and (3) their cytotoxic activity.

Keywords

Iranian Journal of Veterinary Medicine

Articles in Press, Accepted Manuscript
Available Online from 30 April 2024

Files

Share

How to cite

Statistics