Short-term vs. Long-term Effects of Topical administration of latanoprost on Schirmer Tear Test, Intraocular Pressure, and Pupil Size in Clinically Normal Dogs

Articles in Press

Document Type : Original Articles

Authors

1 Department of Clinical Science, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

2 Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

3 Department of Clinical Science, Faculty of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar, Iran.

Abstract


Background: Glaucoma poses significant challenges in veterinary medicine, necessitating
effective management strategies to mitigate vision loss. Prostaglandin analogs like latanoprost
offer promising avenues due to their ability to lower intraocular pressure (IOP). However, a
comprehensive understanding of latanoprost's short-term and long-term effects on ocular
parameters in dogs remains limited.
Objectives: This study aims to compare the effects of short-acting versus long-acting latanoprost
on the Schirmer Tear Test (STT), intraocular pressure (IOP), and pupil size in clinically normal
dogs, highlighting its potential applications in veterinary ophthalmology. By examining both
short-term and long-term impacts, this study offers novel insights into the temporal
pharmacological effects of latanoprost.
Methods: Twenty healthy adult male cross-bred dogs underwent thorough baseline assessments
before receiving either latanoprost or saline drops in randomly chosen eyes over a three-week
period. STT, IOP, and pupil size were measured at various intervals using standardized
protocols. Statistical analysis was conducted to compare treated and untreated eyes.
Results: Short-term analysis revealed significant IOP reduction at 6 and 8 hours post-latanoprost
instillation, with no significant changes in STT values. Pupil diameter showed significant
differences between treated and untreated eyes. Long-term effects included sustained IOP
reduction and pupil constriction after three weeks of latanoprost treatment.
Conclusions: Latanoprost demonstrates rapid and sustained efficacy in reducing IOP in dogs,
with potential implications for glaucoma management. While it does not significantly affect tear
production, it modulates pupil size, highlighting its multifaceted pharmacological effects. The
study affirms latanoprost's safety profile and underscores its therapeutic potential in veterinary
ophthalmology, urging further exploration into its mechanisms and applications.

Keywords

Iranian Journal of Veterinary Medicine

Articles in Press, Accepted Manuscript
Available Online from 06 October 2024

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